Nano Antibiotics: Prospects and Challenges
V.P. Jayachandran
Antibiotic resistance is a major global public health concern, resulting in high healthcare costs, increased morbidity, and mortality. With a limited number of new antibiotics being developed, the emergence and spread of antibacterial resistance poses a constant threat to public health. After 1980s the antibiotic pipeline began to dry up and fewer new drugs were introduced, and microbes seem to be on the winning side in tiding over the barricades built by drugs. Adoption of an effective strategy to intervene the burning issue of MDR is a necessity of the hour. Nanotechnology gives great hope to the medical community in their fight against pathogens. As an essential byproduct nanoantibiotics (nAbts) are being developed by conjugating nanoparticles with antibiotic molecules. Various types of nanoparticles are used as drug delivery systems. This chapter explores the prospects of nAbts, the composition and types of nAbts, their mode of action, challenges faced by nAbts in terms of safety, toxicity, manufacturing complexity, regulatory hurdles etc. as well as development of resistance among bacterial pathogens against nAbts.
Keywords
Multidrug Resistance, Nano Antibiotics, Drug Delivery, Biocompatible, Liposome
Published online 2/10/2024, 30 pages
Citation: V.P. Jayachandran, Nano Antibiotics: Prospects and Challenges, Materials Research Foundations, Vol. 160, pp 83-112, 2024
DOI: https://doi.org/10.21741/9781644902974-4
Part of the book on Nanoparticles in Healthcare
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