Strategies for Enhancing Biocompatibility of Nanoparticles


Strategies for Enhancing Biocompatibility of Nanoparticles

Abhinay Thakur, Ashish Kumar

This book chapter explores the challenges of nanoparticles’ biocompatibility in cardiovascular applications and proposes strategies to enhance their safety profile. It discusses interactions between nanoparticles and biological systems, highlighting factors like size, surface charge, and functionalization. The chapter examines cardiovascular toxicity, including adverse effects on heart function and vascular integrity. Cutting-edge strategies, such as surface modification with polyethylene glycol (PEG) and targeted nanoparticles, are explored to improve biocompatibility and reduce immunogenicity. Stimuli-responsive systems for controlled drug release are also discussed to enhance specificity and minimize off-target effects. These innovations hold promise for advancing nanoparticle applications in medicine.

Nanoparticles, Biocompatibility, Drug Delivery, Surface Modification, Targeted Nanoparticles

Published online 2/10/2024, 43 pages

Citation: Abhinay Thakur, Ashish Kumar, Strategies for Enhancing Biocompatibility of Nanoparticles, Materials Research Foundations, Vol. 161, pp 182-224, 2024


Part of the book on Nanoparticle Toxicity and Compatibility

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