Nanoscale Metal Organic Framework for Phototherapy of Cancer


Nanoscale Metal Organic Framework for Phototherapy of Cancer

Fulya Gülbağça, Fatima Elmusa, Kemal Cellat, Anish Khan, Fatih Şen1

Phototherapy is generally used to describe Ultraviolet B (UVB) therapy, but it is a general term and concept using the non-ionizing electromagnetic radiation and its therapeutic effects Photodynamic therapy (PDT) and Photothermal therapy (PTT) are the basis of phototherapy. In PDT, there is usually a need for Photosensitizers (PSs). In this way, the selectivity, safety and efficiency of phototherapy can be increased via increased singlet oxygen production and photothermal responses in PTT. Effective and selective administration of PSs to diseased tissues is of great importance in both cases. Nano-scale metal-organic frameworks (nMOFs), made of metal anchor points and bridge ligands for high biocompatibility, compositional and structural adjustment, were investigated as nano-carriers for drug delivery as a new class of hybrid materials. This review summarizes the growing and evolving areas of nMOFs as nanoparticle photosensitizers for PDT and PTT.

Nano-Scale Metal-Organic Frameworks, n(MOFs), Cancer, Photodynamic Therapy (PDT), Photothermal Therapy (PTT), Photosensitizers (PSs)

Published online 10/5/2019, 56 pages

Citation: Fulya Gülbağça, Fatima Elmusa, Kemal Cellat, Anish Khan, Fatih Şen1, Nanoscale Metal Organic Framework for Phototherapy of Cancer, Materials Research Foundations, Vol. 58, pp 361-416, 2019


Part of the book on Metal-Organic Framework Composites

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