Emerging Trends of Nanotechnology in Cosmetics


Emerging Trends of Nanotechnology in Cosmetics

Garima Nagpal, Rashi Chaudhary, Ratiram G Chaudhary, N.B. Singh

Cosmetics attract most age groups from teenagers to old age. Cosmetic goods now contain a variety of nanoparticle and nanomaterial types. Nano cosmeceuticals have changed the era of cosmetics as they have advanced delivery mechanisms with task specifications. They are used in nail, hair, lip, and skin care products by cosmetic giants including Estee Lauder, L’oreal, Nivea, Zelens, and Derma Swiss, etc., and have patented the use of dozens of “nanosome particles.” The global market for cosmetics using nanotechnology is worth millions of dollars and increasing at 7.14% annually. Liposomes, niosomes, nanostructured lipid carriers, solid lipid nanoparticles, gold nanoparticles, nanoemulsions, and nanosomes are novel nanocarriers that are now used in a variety of cosmeceuticals for drug delivery to achieve site specification, improved stability, biocompatibility, extended action, and increased drug-loading capacity. In this chapter use of various nanocarriers in cosmetic applications with their safety concerns will be discussed.

Nanomaterial, Nanotechnology, Nano Cosmeceuticals, Cosmetics

Published online , 43 pages

Citation: Garima Nagpal, Rashi Chaudhary, Ratiram G Chaudhary, N.B. Singh, Emerging Trends of Nanotechnology in Cosmetics, Materials Research Foundations, Vol. 148, pp 127-169, 2023

DOI: https://doi.org/10.21741/9781644902554-5

Part of the book on Applications of Emerging Nanomaterials and Nanotechnology

[1] A. Mihranyan, N. Ferraz, and M. Strømme, Current status and prospects of nanotechnology in cosmetics. Progress in Materials Science, 57(5) (2012) pp.875-910. https://doi.org/10.1016/j.pmatsci.2011.10.001
[2] N.A. Ibrahim, and M.A.A. Zaini, Nanomaterials in detergents and cosmetics products: the mechanisms and implications. Handbook of nanomaterials for manufacturing applications, Elsevier. (2012) pp.23-49. https://doi.org/10.1016/B978-0-12-821381-0.00002-8
[3] R. Yadwade, S. Gharpure, and B. Ankamwar, Nanotechnology in cosmetics pros and cons. Nano Express, 2(2) (2021), pp.022003. https://doi.org/10.1088/2632-959X/abf46b
[4] A. Gautam, D. Singh, and R. Vijayaraghavan, Dermal exposure of nanoparticles: an understanding. Journal of Cell and Tissue Research, 11(1) (2011), pp.2703-2708.
[5] R. Saha, Cosmeceuticals and herbal drugs: practical uses. International Journal of Pharmaceutical Sciences and Research, 3(1) (2012), pp.59-65.
[6] K. Srinivas, The current role of nanomaterials in cosmetics. Journal of Chemical and Pharmaceutical Research, 8(5) (2016), pp.906-914.
[7] S. Kaul, N. Gulati, D. Verma, S. Mukherjee, and U. Nagaich, Role of nanotechnology in cosmeceuticals: a review of recent advances. Journal of pharmaceutics, 2 (2018), pp.1-19. https://doi.org/10.1155/2018/3420204
[8] B.H. Abbasi, H. Fazal, N. Ahmad, M. Ali, N. Giglioli-Guivarch, and C. Hano, Nanomaterials for cosmeceuticals: nanomaterials-induced advancement in cosmetics, challenges, and opportunities. Nanocosmetics, (2020) pp.79-108. https://doi.org/10.1016/B978-0-12-822286-7.00005-X
[9] S. Mukta, and F. Adam, Cosmeceuticals in day-to-day clinical practice. Journal of Drugs in Dermatology: JDD, 9(5 Suppl ODAC Conf Pt 1), (2010), pp.s62-6.
[10] A. Lohani, A. Verma, H. Joshi, N. Yadav, and N. Karki, Nanotechnology-based cosmeceuticals. International Scholarly Research Notices, (2014), http://dx.doi.org/10.1155/2014/843687 https://doi.org/10.1155/2014/843687
[11] L.M. Katz, K. Dewan, and R.L. Bronaugh, Nanotechnology in cosmetics. Food and Chemical Toxicology, 85, (2015), pp.127-137. https://doi.org/10.1016/j.fct.2015.06.020
[12] S. Raj, S. Jose, U.S. Sumod, and M. Sabitha, Nanotechnology in cosmetics: Opportunities and challenges. Journal of pharmacy & bioallied sciences, 4(3), (2012), p.186-193. https://doi.org/10.4103/0975-7406.99016
[13] L. Rigano, and N. Lionetti, Nanobiomaterials in galenic formulations and cosmetics. Applied Nanobiomaterials, 10, (2016), pp.121-148. https://doi.org/10.1016/B978-0-323-42868-2.00006-1
[14] C.C. Chang, C.P. Chen, T.H. Wu, C.H. Yang, C.W. Lin, and C.Y. Chen, Gold nanoparticle-based colorimetric strategies for chemical and biological sensing applications. Nanomaterials, 9(6), (2019), https://doi.org/10.3390/nano9060861 https://doi.org/10.3390/nano9060861
[15] G. Ghodake, M. Kim, J.S. Sung, S. Shinde, J. Yang, K. Hwang, and D.Y. Kim, Extracellular synthesis and characterization of silver nanoparticles-Antibacterial activity against multidrug-resistant bacterial strains. Nanomaterials, 10(2), (2020), doi: 10.3390/nano10020360 https://doi.org/10.3390/nano10020360
[16] N. Sharma, S. Singh, N. Kanojia, A.S. Grewal, and S. Arora, Nanotechnology: a modern contraption in cosmetics and dermatology. Applied Clinical Research, Clinical Trials and Regulatory Affairs, 5(3), (2018), pp.147-158. https://doi.org/10.2174/2213476X05666180528093905
[17] G. Miller, L. Archer, E. Pica, D. Bell, R. Senyen, and G. Kimbrell, Nanomaterials, sunscreens and cosmetics: small ingredients, big risks: Friends of the Earth Australia & Friends of the Earth United States. (2006)
[18] T.G. Smijs, and S. Pavel, Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness. Nanotechnology, science and applications, 4, (2011), pp.95-112. https://doi.org/10.2147/NSA.S19419
[19] D.A. Glaser, Anti-aging products and cosmeceuticals. Facial Plastic Surgery Clinics, 12(3), (2004), pp.363-372. https://doi.org/10.1016/j.fsc.2004.03.004
[20] J. Rosen, A. Landriscina, and A.J. Friedman, Nanotechnology-based cosmetics for hair care. Cosmetics, 2(3), (2015), pp.211-224. https://doi.org/10.3390/cosmetics2030211
[21] Z. Hu, M. Liao, Y. Chen, Y. Cai, L. Meng, Y. Liu, N. Lv, Z. Liu, and W. Yuan, A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone. International journal of nanomedicine, 7, (2012), pp.5719-5724. https://doi.org/10.2147/IJN.S37277
[22] C. Fox, Cosmetic and pharmaceutical vehicles: skin care, hair care, makeup and sunscreens. Cosmetics and Toiletries, 113(1), (1998), pp.45-56.
[23] H. Bethany, Zapping nanoparticles into nail polish. Laser Ablation Method Makes Cosmetic and Biomedical Coatings in a Flash, 95(12), (2017), pp.9.
[24] L. Pereira, N. Dias, J. Carvalho, S. Fernandes, C. Santos, and N. Lima, Synthesis, characterization and antifungal activity of chemically and fungal‐produced silver nanoparticles against T richophyton rubrum. Journal of applied microbiology, 117(6), (2014), pp.1601-1613. https://doi.org/10.1111/jam.12652
[25] P.T. Sundari, and H. Anushree, Novel delivery systems: current trend in cosmetic industry. European Journal of Pharmaceutical and Medical Research, 4(8), (2017), pp.617-627.
[26] N. Arora, S. Agarwal, and R.S.R. Murthy, Latest technology advances in cosmaceuticals. Int. J. Pharm. Sci. Drug Res, 4(3), (2012), pp.168-182.
[27] M.J. Hope, and C.N. Kitson, Liposomes: a perspective for dermatologists. Dermatologic clinics, 11(1), (1993), pp.143-154. https://doi.org/10.1016/S0733-8635(18)30291-2
[28] B.G. Prajapati, N.K. Patel, N.M. Panchal, and R.P. Patel, Topical liposomes in drug delivery: a review. International Journal of Pavement Research and Technology, 4(1), (2012), pp.39-44.
[29] I.P. Kaur, and R. Agrawal, Nanotechnology: a new paradigm in cosmeceuticals. Recent patents on drug delivery & formulation, 1(2), (2007), pp.171-182. https://doi.org/10.2174/187221107780831888
[30] S.K. Sriraman, and V.P. Torchilin, Recent advances with liposomes as drug carriers. Advanced Biomaterials and Biodevices, 1, (2014), pp.79-120. https://doi.org/10.1002/9781118774052.ch3
[31] D.D. Lasic, Novel applications of liposomes. Trends in biotechnology, 16(7), (1998) pp.307-321. https://doi.org/10.1016/S0167-7799(98)01220-7
[32] C.C. Müller-Goymann, Physicochemical characterization of colloidal drug delivery systems such as reverse micelles, vesicles, liquid crystals and nanoparticles for topical administration. European Journal of Pharmaceutics and Biopharmaceutics, 58(2), (2004), pp.343-356. https://doi.org/10.1016/j.ejpb.2004.03.028
[33] K. Egbaria, and N. Weiner, Liposomes as a topical drug delivery system. Advanced drug delivery reviews, 5(3), (1990), pp.287-300. https://doi.org/10.1016/0169-409X(90)90021-J
[34] M.M. Rieger, Skin lipids and their importance to cosmetic science. Cosmetics and Toiletries, 102(7), (1987), pp.45-49.
[35] G. Blume, E. Teichmüller, and E. Teichmüller, New evidence of the penetration of actives by liposomal carrier system. Cosmetics & Toiletries Manufacture Worldwide, (1997), pp.135-139.
[36] M. Ghyczy, H.P. Nissen, and H. Biltz, The treatment of acne vulgaris by phosphatidylcholine from soybeans, with a high content of linoleic acid. Journal of applied cosmetology, 14, (1996), pp.137-146.
[37] G. Blume, Flexible liposomes for topical applications in cosmetics. Science and applications of skin delivery systems,(2008), pp.269-282.
[38] A. Akbarzadeh, R. Rezaei-Sadabady, S. Davaran, S.W. Joo, N. Zarghami, Y. Hanifehpour, M. Samiei, M. Kouhi, and K. Nejati-Koshki, Liposome: classification, preparation, and applications. Nanoscale research letters, 8(1), (2013), pp.1-9. https://doi.org/10.1186/1556-276X-8-102
[39] Dermosome, https://www.ulprospector.com/en/la/personalcare/Detail/1832/44044/ Dermosomes.
[40] Decorte, https://www.decortecosmetics.com/skincare/liposome
[41] K.M. Kazi, A.S. Mandal, N. Biswas, A. Guha, S. Chatterjee, M. Behera, and K. Kuotsu, Niosome: a future of targeted drug delivery systems. Journal of Advanced Pharmaceutical Technology & Research, 1(4), (2010), pp.374-380. https://doi.org/10.4103/0110-5558.76435
[42] S. Duarah, K. Pujari, R.D. Durai, and V.H.B. Narayanan, Nanotechnology-based cosmeceuticals: a review. International Journal of Applied Pharmaceuticals, 8(1), (2016), pp.8-12.
[43] A. Sankhyan, and P. Pawar, Current trends in niosome as vesicular drug delivery system. Asian Journal of Pharmacy and Life Science, 02(06), (2012) pp.20-32.
[44] P. Sudheer, and K. Kaushik, Review on niosomes-a novel approach for drug targeting. Journal of Pharmaceutical Research, 14(1), (2015), pp.20-25. https://doi.org/10.18579/jpcrkc/2015/14/1/78376
[45] V. Pola Chandu, A. Arunachalam, S. Jeganath, K. Yamini, and K. Tarangini, Niosomes: a novel drug delivery system. International Journal of Novel Trends in Pharmaceutical Sciences, 2(1), (2012), pp. 2277-2782.
[46] G.P. Kumar, and P. Rajeshwarrao, Nonionic surfactant vesicular systems for effective drug delivery-an overview. Acta Pharmaceutica Sinica B, 1(4), (2011), pp.208-219. https://doi.org/10.1016/j.apsb.2011.09.002
[47] S. Biswal, P.N. Murthy, J. Sahu, P. Sahoo, and F. Amir, Vesicles of non-ionic surfactants (niosomes) and drug delivery potential. International journal of Pharmaceutical Sciences and Nanotechnology, 1(1), (2008), pp.1-8. https://doi.org/10.37285/ijpsn.2008.1.1.1
[48] A. Nasir, S.L. Harikumar, and K. Amanpreet, Niosomes: An excellent tool for drug delivery. International Journal of Research in Pharmacy and Chemistry, 2(2), (2012), pp.479-487.
[49] M. Gandhi, P. Sanket, and S. Mahendra, Niosomes: novel drug delivery system. International Journal of Pure & Applied Bioscience, 2(2), (2014), pp.267-274.
[50] S. Verma, S.K. Singh, N. Syan, P. Mathur, and V. Valecha, Nanoparticle vesicular systems: a versatile tool for drug delivery. Journal of Chemical and Pharmaceutical Research, 2(2), (2010), pp.496-509.
[51] T. Varun, A. Sonia, P. Bharat, V. Patil, P.O. Kumharhatti, and D. Solan, Niosomes and liposomes-vesicular approach towards transdermal drug delivery. International Journal of Pharmaceutical and Chemical Sciences, 1(3), (2012), pp.632-644.
[52] A. Gupta, S.K. Prajapati, M. Balamurugan, M. Singh, and D. Bhatia, Design and development of a proniosomal transdermal drug delivery system for captopril. Tropical Journal of Pharmaceutical Research, 6(2), (2007), pp.687-693. https://doi.org/10.4314/tjpr.v6i2.14647
[53] S. Waghmare, A. Patil, and P. Patil, Novasome: Advance in Liposome and Niosome. The Pharma Innovation, 5(5), (2016), pp.34.
[54] S. Mosallam, M.H. Ragaie, N.H. Moftah, A.H. Elshafeey, and A.A. Abdelbary, Use of novasomes as a vesicular carrier for improving the topical delivery of terconazole: In vitro characterization, in vivo assessment and exploratory clinical experimentation. International Journal of Nanomedicine, 16, (2021) pp.119-132. https://doi.org/10.2147/IJN.S287383
[55] A. Singh, R. Malviya, and P.K. Sharma, Novasome-a breakthrough in pharmaceutical technology a review article. Advances in Biological Research, 5(4), (2011), pp.184-189.
[56] B. Gorain, B.E. Al-Dhubiab, A. Nair, P. Kesharwani, M. Pandey, and H. Choudhury, Multivesicular liposome: A lipid-based drug delivery system for efficient drug delivery. Current Pharmaceutical Design, 27(43), (2021), pp.4404-4415. https://doi.org/10.2174/1381612827666210830095941
[57] D. Puri, A. Bhandari, P. Sharma, and D. Choudhary, Lipid nanoparticles (SLN, NLC): A novel approach for cosmetic and dermal pharmaceutical. Journal of Global Pharma Technology, 2(9), (2010), pp.1-15.
[58] N. Hasan, M. Imran, P. Kesharwani, K. Khanna, R. Karwasra, N. Sharma, S. Rawat, D. Sharma, F.J. Ahmad, G.K. Jain, and A. Bhatnagar, Intranasal delivery of Naloxone-loaded solid lipid nanoparticles as a promising simple and non-invasive approach for the management of opioid overdose. International Journal of Pharmaceutics, 599, (2021), doi: 10.1016/j.ijpharm.2021.120428. https://doi.org/10.1016/j.ijpharm.2021.120428
[59] G.S. Bhagwat, R.B. Athawale, R.P. Gude, S. Md, N.A. Alhakamy, U.A. Fahmy, and P. Kesharwani, Formulation and development of transferrin targeted solid lipid nanoparticles for breast cancer therapy. Frontiers in Pharmacology, 11, (2020), doi: 10.3389/fphar.2020.614290. https://doi.org/10.3389/fphar.2020.614290
[60] R.K. Khurana, R. Kumar, B.L. Gaspar, G. Welsby, P. Welsby, P. Kesharwani, O.P. Katare, K.K. Singh, and B. Singh, Clathrin-mediated endocytic uptake of PUFA enriched self-nanoemulsifying lipidic systems (SNELS) of an anticancer drug against triple negative cancer and DMBA induced preclinical tumor model. Materials Science and Engineering: C, 91, (2018), pp.645-658. https://doi.org/10.1016/j.msec.2018.05.010
[61] R.K. Khurana, S. Beg, A.J. Burrow, R.K. Vashishta, O.P. Katare, S. Kaur, P. Kesharwani, K.K. Singh, and B. Singh, Enhancing biopharmaceutical performance of an anticancer drug by long chain PUFA based self-nanoemulsifying lipidic nanomicellar systems. European Journal of Pharmaceutics and Biopharmaceutics, 121, (2017), pp.42-60. https://doi.org/10.1016/j.ejpb.2017.09.001
[62] A. Jain, G. Sharma, V. Kushwah, N.K. Garg, P. Kesharwani, G. Ghoshal, B. Singh, U.S. Shivhare, S. Jain, and O.P. Katare, Methotrexate and beta-carotene loaded-lipid polymer hybrid nanoparticles: A preclinical study for breast cancer. Nanomedicine, 12(15), (2017), pp.1851-1872. https://doi.org/10.2217/nnm-2017-0011
[63] A. Zur Mühlen, C. Schwarz, and W. Mehnert, Solid lipid nanoparticles (SLN) for controlled drug delivery-drug release and release mechanism. European Journal of Pharmaceutics and Biopharmaceutics, 45(2), (1998), pp.149-155. https://doi.org/10.1016/S0939-6411(97)00150-1
[64] J. Pardeike, A. Hommoss, and R.H. Müller, Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. International Journal of Pharmaceutics, 366(1-2), (2009), pp.170-184. https://doi.org/10.1016/j.ijpharm.2008.10.003
[65] A. Patidar, D.S. Thakur, P. Kumar, and J. Verma, A review on novel lipid based nanocarriers. International Journal of Pharmacy and Pharmaceutical Sciences, 2(4), (2010), pp.30-35.
[66] C. Song, and S. Liu, A new healthy sunscreen system for human: Solid lipid nannoparticles as carrier for 3, 4, 5-trimethoxybenzoylchitin and the improvement by adding Vitamin E. International Journal of Biological Macromolecules, 36(1-2), (2005), pp.116-119. https://doi.org/10.1016/j.ijbiomac.2005.05.003
[67] R.H. Müller, M. Radtke, and S.A. Wissing, Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Advanced Drug Delivery Reviews, 54, (2002), pp.131-S155. https://doi.org/10.1016/S0169-409X(02)00118-7
[68] M. Hassan Hany, O.N. El Gazayerly, Rice bran solid lipid nanoparticles: Preparation and characterization. International Journal of Research in Drug Delivery, 1(2), (2011), pp.6-9.
[69] R. López-García, and A. Ganem-Rondero, Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC): occlusive effect and penetration enhancement ability. Journal of Cosmetics, Dermatological Sciences and Applications, 5(2), (2015), pp.62-72. https://doi.org/10.4236/jcdsa.2015.52008
[70] E.B. Souto, and R.H. Müller, Cosmetic features and applications of lipid nanoparticles (SLN®, NLC®). International Journal of Cosmetic Science, 30(3), (2008), pp.157-165. https://doi.org/10.1111/j.1468-2494.2008.00433.x
[71] P. Ekambaram, A.H. Sathali and K. Priyanka, Solid lipid nanoparticles: a review. Scientific Reviews and Chemical Communications, 2(1), (2012), pp. 80-102.
[72] K.H. Ramteke, S.A. Joshi, and S.N. Dhole, Solid lipid nanoparticle: a review. IOSR Journal of Pharmacy, 2(6), (2012), pp.34-44. https://doi.org/10.9790/3013-26103444
[73] R. Costa, and L. Santos, Delivery systems for cosmetics-From manufacturing to the skin of natural antioxidants. Powder Technology, 322, (2017), pp.402-416. https://doi.org/10.1016/j.powtec.2017.07.086
[74] D.K. Purohit, Nano-lipid carriers for topical application: Current scenario. Asian Journal of Pharmaceutics, 10(1), (2016), https://doi.org/10.22377/ajp.v10i1.544
[75] K. Westesen, H. Bunjes, and M.J.H. Koch, Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential. Journal of Controlled Release, 48(2-3), (1997), pp.223-236. https://doi.org/10.1016/S0168-3659(97)00046-1
[76] S. Khan, S. Baboota, J. Ali, S. Khan, R.S. Narang, and J.K. Narang, Nanostructured lipid carriers: an emerging platform for improving oral bioavailability of lipophilic drugs. International Journal of Pharmaceutical Investigation, 5(4), (2015), pp.182-191. https://doi.org/10.4103/2230-973X.167661
[77] B. Sharma, and A. Sharma, Future prospect of nanotechnology in development of anti-ageing formulations. International Journal of Pharmacy and Pharmaceutical Sciences, 4(3), (2012), pp.57-66.
[78] N. Naseri, H. Valizadeh, and P. Zakeri-Milani, Solid lipid nanoparticles and nanostructured lipid carriers: structure, preparation and application. Advanced Pharmaceutical Bulletin, 5(3), (2015), pp.305-313. https://doi.org/10.15171/apb.2015.043
[79] S. Kaur, U. Nautyal, R. Singh, S. Singh, and A. Devi, Nanostructure lipid carrier (NLC): the new generation of lipid nanoparticles. Asian Pacific Journal of Health Sciences, 2(2), (2015), pp.76-93. https://doi.org/10.21276/apjhs.2015.2.2.14
[80] C.L. Fang, S.A. Al-Suwayeh, and J.Y. Fang, Nanostructured lipid carriers (NLCs) for drug delivery and targeting. Recent patents on nanotechnology, 7(1), (2013), pp.41-55. https://doi.org/10.2174/187221013804484827
[81] A. Singh, G. Garg, and P.K. Sharma, Nanospheres: a novel approach for targeted drug delivery system. International Journal of Pharmaceutical Sciences Review and Research, 5(3), (2010), pp.84-88.
[82] B. Mamo, W. Abebe, and T.D. Gabriel, Literature review on biodegradable nanospheres for oral and targeted drug delivery. Asian Journal of Biomedical and Pharmaceutical Sciences, 5(51), (2015), pp.01-12. https://doi.org/10.15272/ajbps.v5i51.761
[83] S.S. Guterres, M.P. Alves, and A.R. Pohlmann, Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications. Drug Target Insights, 2, (2007), pp.147-157. https://doi.org/10.1177/117739280700200002
[84] B. Gorain, H. Choudhury, A.B. Nair, S.K. Dubey, and P. Kesharwani, Theranostic application of nanoemulsions in chemotherapy. Drug Discovery Today, 25(7), (2020), pp.1174-1188. https://doi.org/10.1016/j.drudis.2020.04.013
[85] H. Choudhury, N.F.B. Zakaria, P.A.B. Tilang, A.S. Tzeyung, M. Pandey, B. Chatterjee, N.A. Alhakamy, S.K. Bhattamishra, P. Kesharwani, B. Gorain, and S. Md, Formulation development and evaluation of rotigotine mucoadhesive nanoemulsion for intranasal delivery. Journal of Drug Delivery Science and Technology, 54, (2019), 101301. doi: 10.1016/j.jddst.2019.101301. https://doi.org/10.1016/j.jddst.2019.101301
[86] H. Choudhury, M. Pandey, B. Gorain, B. Chatterjee, T. Madheswaran, S. Md, K.K. Mak, M. Tambuwala, M.K. Chourasia, and P. Kesharwani, Nanoemulsions as effective carriers for the treatment of lung cancer. In Nanotechnology-based targeted drug delivery systems for lung cancer, (2019), pp. 217-247. https://doi.org/10.1016/B978-0-12-815720-6.00009-5
[87] M. Pandey, H. Choudhury, O.C. Yeun, H.M. Yin, T.W. Lynn, C.L. Tine, N.S. Wi, K.C. Yen, C.S. Phing, P. Kesharwani, and S.K. Bhattamisra, Perspectives of nanoemulsion strategies in the improvement of oral, parenteral and transdermal chemotherapy. Current pharmaceutical biotechnology, 19(4), (2018), pp.276-292. https://doi.org/10.2174/1389201019666180605125234
[88] H. Choudhury, B. Gorain, M. Pandey, L.A. Chatterjee, P. Sengupta, A. Das, N. Molugulu, and P. Kesharwani, Recent update on nanoemulgel as topical drug delivery system. Journal of Pharmaceutical Sciences, 106(7), (2017), pp.1736-1751. https://doi.org/10.1016/j.xphs.2017.03.042
[89] M.F.R.G. Dias, Educational Website for Cosmetologists.
[90] O. Sonneville-Aubrun, M. Yukuyama, and A. Pizzino, Application of nanoemulsions in cosmetics. Nanoemulsions: Formulation, Applications and Characterization. Elsevier Inc; (2018). https://doi.org/10.1016/B978-0-12-811838-2.00014-X
[91] T.J. Ashaolu, Nanoemulsions for health, food, and cosmetics: A review. Environmental Chemistry Letters, 19(4), (2021), pp.3381-3395. https://doi.org/10.1007/s10311-021-01216-9
[92] Z.A.A. Aziz, H. Mohd-Nasir, A. Ahmad, S.H. Mohd. Setapar, W.L., Peng, S.C. Chuo, A. Khatoon, K. Umar, A.A. Yaqoob, and M.N. Mohamad Ibrahim, Role of nanotechnology for design and development of cosmeceutical: application in makeup and skin care. Frontiers in Chemistry, 7, (2019), https://doi.org/10.3389/fchem.2019.00739 https://doi.org/10.3389/fchem.2019.00739
[93] A. Sheikh, S. Md, and P. Kesharwani, RGD engineered dendrimer nanotherapeutic as an emerging targeted approach in cancer therapy. Journal of Controlled Release, 340, (2021), pp.221-242. https://doi.org/10.1016/j.jconrel.2021.10.028
[94] S.K. Dubey, A. Dey, G. Singhvi, M.M. Pandey, V. Singh, and P. Kesharwani, Emerging trends of nanotechnology in advanced cosmetics. Colloids and Surfaces B: Biointerfaces, (2022), doi: 10.1016/j.colsurfb.2022.112440. https://doi.org/10.1016/j.colsurfb.2022.112440
[95] E.B. Souto, A.R. Fernandes, C. Martins-Gomes, T.E. Coutinho, A. Durazzo, M. Lucarini, S.B. Souto, A.M. Silva, and A. Santini, Nanomaterials for skin delivery of cosmeceuticals and pharmaceuticals. Applied Sciences, 10(5), (2020), https://doi.org/10.3390/app10051594. https://doi.org/10.3390/app10051594
[96] C. Yang, M. Wang, J. Zhou, and Q. Chi, Bio-synthesis of peppermint leaf extract polyphenols capped nano-platinum and their in-vitro cytotoxicity towards colon cancer cell lines (HCT 116). Materials Science and Engineering: C, 77, (2017), pp.1012-1016. https://doi.org/10.1016/j.msec.2017.04.020
[97] S. Joglekar, K. Kodam, M. Dhaygude, and M. Hudlikar, Novel route for rapid biosynthesis of lead nanoparticles using aqueous extract of Jatropha curcas L. latex. Materials Letters, 65(19-20), (2011), pp.3170-3172. https://doi.org/10.1016/j.matlet.2011.06.075
[98] A.K. Potbhare, R.G. Chaudhary, P.B. Chouke, S. Yerpude, A. Mondal, V.N. Sonkusare, A.R. Rai, and H.D. Juneja, Phytosynthesis of nearly monodisperse CuO nanospheres using Phyllanthus reticulatus/Conyza bonariensis and its antioxidant/antibacterial assays. Materials Science and Engineering: C, 99, (2019), pp.783-793. https://doi.org/10.1016/j.msec.2019.02.010
[99] A.C. Paiva-Santos, A.M. Herdade, C. Guerra, D. Peixoto, M. Pereira-Silva, M. Zeinali, F. Mascarenhas-Melo, A. Paranhos, and F. Veiga, Plant-mediated green synthesis of metal-based nanoparticles for dermopharmaceutical and cosmetic applications. International Journal of Pharmaceutics, 597, (2021), DOI:10.1016/j.ijpharm.2021.120311. https://doi.org/10.1016/j.ijpharm.2021.120311
[100] R. Alsubki, H. Tabassum, M. Abudawood, A.A. Rabaan, S.F. Alsobaie, and S. Ansar, Green synthesis, characterization, enhanced functionality and biological evaluation of silver nanoparticles based on Coriander sativum. Saudi Journal of Biological Sciences, 28(4), (2021), pp.2102-2108. https://doi.org/10.1016/j.sjbs.2020.12.055
[101] F. Sabir, M. Barani, A. Rahdar, M. Bilal, and M. Nadeem, How to face skin cancer with nanomaterials: A review. Biointerface Research in Applied Chemistry, 11, (2021), pp.11931-11955. https://doi.org/10.33263/BRIAC114.1193111955
[102] H. Pastrana, A. Avila, and C.S. Tsai, Nanomaterials in cosmetic products: The challenges with regard to current legal frameworks and consumer exposure. Nanoethics, 12(2), (2018), pp.123-137. https://doi.org/10.1007/s11569-018-0317-x
[103] F. Carrouel, S. Viennot, L. Ottolenghi, C. Gaillard, and D. Bourgeois, Nanoparticles as anti-microbial, anti-inflammatory, and remineralizing agents in oral care cosmetics: a review of the current situation. Nanomaterials, 10(1), (2020), doi: 10.3390/nano10010140. https://doi.org/10.3390/nano10010140
[104] R.A. Revia, B.A., Wagner, and M. Zhang, A portable electrospinner for nanofiber synthesis and its application for cosmetic treatment of alopecia. Nanomaterials, 9(9), (2019), doi: 10.3390/nano9091317. https://doi.org/10.3390/nano9091317
[105] U. Ahmad, Z. Ahmad, A.A. Khan, J. Akhtar, S.P. Singh, and F.J. Ahmad, Strategies in development and delivery of nanotechnology based cosmetic products. Drug Research, 68(10), (2018), pp.545-552. https://doi.org/10.1055/a-0582-9372
[106] C. Ngô, and M.H. Van de Voorde, Nanomaterials and cosmetics. Nanotechnology in a Nutshell (2014), pp. 311-319. https://doi.org/10.2991/978-94-6239-012-6_18
[107] J. Cornier, C.M. Keck, and M. Van de Voorde, Nanocosmetics: From Ideas to Products. Springer (2019). https://doi.org/10.1007/978-3-030-16573-4
[108] L.A. Huber, T.A. Pereira, D.N. Ramos, L.C. Rezende, F.s. Emery, L.M. Sobral, A.M. Leopoldino, and R.F. Lopez, Topical skin cancer therapy using doxorubicin-loaded cationic lipid nanoparticles and iontophoresis. Journal of Biomedical Nanotechnology, 11(11), (2015), pp.1975-1988. https://doi.org/10.1166/jbn.2015.2139
[109] M.R. Santos, A.C. Fonseca, P.V. Mendonça, R. Branco, A.C. Serra, P.V. Morais, and J.F. Coelho, Recent developments in antimicrobial polymers: A review. Materials, 9(7), (2016), doi:10.3390/ma9070599. https://doi.org/10.3390/ma9070599
[110] P. Morganti, New horizon in cosmetic dermatology. J. Appl. Cosmetol, 34, (2016), pp.15-24.
[111] N. Dragicevic, and H.I. Maibach, Percutaneous penetration enhancers physical methods in penetration enhancement. New York, NY, USA: Springer (2017). https://doi.org/10.1007/978-3-662-53273-7
[112] A. Singh, G. Garg, and P.K. Sharma, Nanospheres: a novel approach for targeted drug delivery system. International Journal of Pharmaceutical Sciences Review and Research, 5(3), (2010), pp.84-88.
[113] H. Idrees, S.J.Z. Zaidi, A. Sabir, R.U. Khan, X. Zhang, and S. Hassan, A review of biodegradable natural polymer based nanoparticles for drug delivery applications. Nanomaterials, 10(10), (2020), https://doi.org/10.3390/nano10101970 https://doi.org/10.3390/nano10101970
[114] S. Deng, M.R. Gigliobianco, R. Censi, and P.D. Martino, Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities. Nanomaterials, 10(5), (2020), https://doi.org/10.3390/nano10050847 https://doi.org/10.3390/nano10050847
[115] D.A. Fernandes, Review on the applications of nanoemulsions in cancer theranostics. Journal of Materials Research, 37, (2022), pp.1953-1977. https://doi.org/10.1557/s43578-022-00583-5
[116] S. Kato, H. Aoshima, Y. Saitoh, and N. Miwa, Defensive effects of fullerene-C60 dissolved in squalane against the 2, 4-nonadienal-induced cell injury in human skin keratinocytes HaCaT and wrinkle formation in 3D-human skin tissue model. Journal of Biomedical Nanotechnology, 6(1), (2010), pp.52-58. https://doi.org/10.1166/jbn.2010.1091
[117] T.M. Benn, P. Westerhoff, and P. Herckes, Detection of fullerenes (C60 and C70) in commercial cosmetics. Environmental Pollution, 159(5), (2011), pp.1334-1342. https://doi.org/10.1016/j.envpol.2011.01.018
[118] Z.D. Draelos, Retinoids in cosmetics. Cosmetic Dermatology, 18(1), (2005), pp.3-5.
[119] B.H. Jung, Y.T. Lim, J.K. Kim, J.Y. Jeong, and T.H. Ha, Cosmetic pigment composition containing gold or silver nano-particles. (2008), European Patent 1909745A1.
[120] S.M. Hirst, A.S. Karakoti, R.D. Tyler, N. Sriranganathan, S. Seal, and C.M. Reilly, Anti‐inflammatory properties of cerium oxide nanoparticles. Small, 5(24), (2009), pp.2848-2856. https://doi.org/10.1002/smll.200901048
[121] C. Couteau, and L. Coiffard, Overview of skin whitening agents: Drugs and cosmetic products. Cosmetics, 3(3), (2016). https://doi.org/10.3390/cosmetics3030027
[122] G.M. Turino, and J.O. Cantor, Hyaluronan in respiratory injury and repair. American Journal of Respiratory and Critical Care Medicine, 167(9), (2003), pp.1169-1175. https://doi.org/10.1164/rccm.200205-449PP
[123] P. Maitra, S. Carlo, and R.A. Ranade, Nanoparticle Compositions Providing Enhanced Color for Cosmetic Formulations. (2014), U.S. Patent Application 14/040,800.
[124] J.D. Dreher, G.J. Stepniewski, Optical makeup composition. Patent no. CA 2366619 C; (2008).
[125] A.S. Barnard, One-to-one comparison of sunscreen efficacy, aesthetics and potential nanotoxicity. Nature nanotechnology, 5(4), (2010), pp.271-274. https://doi.org/10.1038/nnano.2010.25
[126] D. Schlossman, E,.Bartholomey, and C. Orr, Kobo Products Inc, Uv protective cosmetic product incorporating titanium dioxide and transparent iron oxide. (2010) U.S. Patent Application 12/515,395.
[127] J. Vollhardt, N. Malkan, and R.P. Manzo, Dragoco Gerberding and Co GmbH. Process for producing cosmetic and pharmaceutical formulations, and products comprising same. (2002), U.S. Patent 6,387,398.
[128] M. Herstein,, Cosmetic skin-renewal-stimulating composition with long-term irritation control. (1997), U.S. Patent 5,616,332.
[129] Z.V.Q. Jurado, M.A.W. Mendoza, L.M.C. Covarrubias, H.M.A. Bandin, and J.E.P. Lopez, Antibacterial composition of silver nanoparticles bonded to a dispersing agent. Patent no. WO 2016 122995 A1; 2016 https://doi.org/10.1155/2016/1641352
[130] H.W. Lee, OROSCIENCE Inc, Process to form nano-sized materials, the compositions and uses thereof. (2009), U.S. Patent Application 11/933,397.
[131] R.M. Hoffman, Topical liposome targeting of dyes, melanins, genes, and proteins selectively to hair follicles. Journal of Drug Targeting, 5(2), (1998), pp.67-74. https://doi.org/10.3109/10611869808995860
[132] M. Franzke, K. Steinbrecht, T. Clausen, S. Baecker, J. Titze, and G.M.B.H. Wella, Cosmetic compositions for hair treatment containing dendrimers or dendrimer conjugates. (2000), U.S. Patent 6,068,835.
[133] H. Furukawa, and T. Limura, Copolymer having carbosiloxane dendrimer structure, and composition and cosmetic containing the same. (2012) Patent no. US 2012 0263662 A1;
[134] F. Giroud, H. Samain, and I. Rollat, Loreal, S.A., Cosmetic composition based on nanoparticles and on water-soluble organic silicon compounds. (2013), U.S. Patent 8,377,427.
[135] J.L. Gesztesi, L.M. Santos, P.D.T. Hennies, and K.A. Macian, Natura Cosmeticos SA, Oil-in-water nanoemulsion, a cosmetic composition and a cosmetic product comprising it, a process for preparing said nanoemulsion. (2015), U.S. Patent 8,956,597.
[136] S.R. Fogg, T.R. Kapsner, and P. Matravers, Hair treatment composition and method. (1999), Patent no. WO 1999 055293 A1.
[137] S. Dickhof, J. Franklin, P. Busch, C. Kropf, and D. Fischer, Cosmetic composition, for preventing greasy appearance on hair, contains nanoparticles of oxide, oxide-hydrate, hydroxide, carbonate, silicate or phosphate of calcium, magnesium, aluminum, titanium, zirconium or zinc. (2001), Patent DE19946784 A, 12001, p.19.
[138] M. Mellul, S.A. LOreal, Cosmetic make-up composition containing a fullerene or mixture of fullerenes as a pigmenting agent. (1997), U.S. Patent 5,612,021.
[139] P.J. Borm, D. Robbins, S. Haubold, T. Kuhlbusch, H. Fissan, K. Donaldson, R. Schins, V. Stone, W. Kreyling, J. Lademann, and J. Krutmann, The potential risks of nanomaterials: a review carried out for ECETOC. Particle and Fibre toxicology, 3(1), (2006), pp.1-35. https://doi.org/10.1186/1743-8977-3-11
[140] Z. Zhou, R. Lenk, A. Dellinger, D. MacFarland, K. Kumar, S.R. Wilson, and C.L. Kepley, Fullerene nanomaterials potentiate hair growth. Nanomedicine: Nanotechnology, Biology and Medicine, 5(2), (2009), pp.202-207. https://doi.org/10.1016/j.nano.2008.09.005
[141] F. Giroud, and V. Favreau, LOreal SA, Cosmetic composition for volumizing keratin fibers and cosmetic use of nanotubes for volumizing keratin fibers. (2004), U.S. Patent Application 10/455,499.
[142] X. Huang, R.K. Kobos, and G. Xu, EI Du Pont de Nemours and Co, Hair coloring and cosmetic compositions comprising carbon nanotubes. (2007), U.S. Patent 7,276,088.
[143] V. Jeanne-Rose, Cosmetic composition comprising a dyestuff said dyestuff and cosmetic treatment process. Patent no. WO 2012 035029 A2; 2012.
[144] C. Buzea, I.I. Pacheco, and K. Robbie, Nanomaterials and nanoparticles: sources and toxicity. Biointerphases, 2(4), (2007), pp.17-71. https://doi.org/10.1116/1.2815690
[145] C.S. Yah, S.E. Iyuke, and G.S. Simate, A review of nanoparticles toxicity and their routes of exposures. Iranian Journal of Pharmaceutical Sciences, 8(1), (2012), pp.299-314.
[146] M.T. Zhu, W.Y. Feng, Y. Wang, B. Wang, M. Wang, H. Ouyang, Y.L. Zhao, and Z.F. Chai, Particokinetics and extrapulmonary translocation of intratracheally instilled ferric oxide nanoparticles in rats and the potential health risk assessment. Toxicological Sciences, 107(2), (2009), pp.342-351. https://doi.org/10.1093/toxsci/kfn245
[147] P.H. Hoet, I. Brüske-Hohlfeld, and O.V. Salata, Nanoparticles-known and unknown health risks. Journal of Nanobiotechnology, 2(1), (2004), pp.1-15. https://doi.org/10.1186/1477-3155-2-12
[148] A. Nel, T. Xia, L. Madler, and N. Li, Toxic potential of materials at the nanolevel. Science, 311(5761), (2006), pp.622-627. https://doi.org/10.1126/science.1114397
[149] V.K. Poon, and A. Burd, In vitro cytotoxity of silver: implication for clinical wound care. Burns, 30(2), (2004), pp.140-147. https://doi.org/10.1016/j.burns.2003.09.030
[150] T.G. Singh, and N. Sharma, Nanobiomaterials in cosmetics: current status and future prospects. Nanobiomaterials in Galenic Formulations and Cosmetics, (2016), pp.149-174. https://doi.org/10.1016/B978-0-323-42868-2.00007-3
[151] G. Wakefield, S. Lipscomb, E. Holland, and J. Knowland, The effects of manganese doping on UVA absorption and free radical generation of micronised titanium dioxide and its consequences for the photostability of UVA absorbing organic sunscreen components. Photochemical & Photobiological Sciences, 3(7), (2004), pp.648-652. https://doi.org/10.1039/b403697b
[152] A. Mavon, C. Miquel, O. Lejeune, B. Payre, and P. Moretto, In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen. Skin Pharmacology and Physiology, 20(1), (2007), pp.10-20. https://doi.org/10.1159/000096167
[153] C.M. Sayes, J.D. Fortner, W. Guo, D. Lyon, A.M. Boyd, K.D. Ausman, Y.J. Tao, B. Sitharaman, L.J. Wilson, J.B. Hughes, and J.L. West, The differential cytotoxicity of water-soluble fullerenes. Nano letters, 4(10), (2004), pp.1881-1887. https://doi.org/10.1021/nl0489586
[154] B. Arvidson, A review of axonal transport of metals. Toxicology, 88(1-3), (1994), pp.1-14. https://doi.org/10.1016/0300-483X(94)90107-4
[155] H. Shi, R. Magaye, V. Castranova, and J. Zhao, Titanium dioxide nanoparticles: a review of current toxicological data. Particle and Fibre Toxicology, 10(1), (2013), pp.1-33. https://doi.org/10.1186/1743-8977-10-15
[156] O.M. Posada, R.J. Tate, and M.H. Grant, Toxicity of cobalt-chromium nanoparticles released from a resurfacing hip implant and cobalt ions on primary human lymphocytes in vitro. Journal of Applied Toxicology, 35(6), (2015), pp.614-622. https://doi.org/10.1002/jat.3100
[157] R.J. Aitken, M.Q. Chaudhry, A.B.A. Boxall, and M. Hull, Manufacture and use of nanomaterials: current status in the UK and global trends. Occupational Medicine, 56(5), (2006), pp.300-306. https://doi.org/10.1093/occmed/kql051
[158] I. Khan, K. Saeed, and I. Khan, Nanoparticles: properties, applications and toxicities. Arabian Journal of Chemistry, 12(7), (2017), pp. 908-931. https://doi.org/10.1016/j.arabjc.2017.05.011
[159] J. Chen, X. Dong, J. Zhao, and G. Tang, In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection. Journal of applied toxicology, 29(4), (2009), pp.330-337. https://doi.org/10.1002/jat.1414
[160] F. Gottschalk, T. Sonderer, R.W. Scholz, and B. Nowack, Modeled environmental concentrations of engineered nanomaterials (TiO2, ZnO, Ag, CNT, fullerenes) for different regions. Environmental Science & Technology, 43(24), (2009), pp.9216-9222. https://doi.org/10.1021/es9015553
[161] J. Sun, S. Wang, D. Zhao, F.H. Hun, L. Weng, and H. Liu, Cytotoxicity, permeability, and inflammation of metal oxide nanoparticles in human cardiac microvascular endothelial cells. Cell Biology and Toxicology, 27(5), (2011), pp.333-342. https://doi.org/10.1007/s10565-011-9191-9
[162] E. Hood, Fullerenes and fish brains: nanomaterials cause oxidative stress (2004). https://doi.org/10.1289/ehp.112-a568a
[163] C. Fruijtier-Pölloth, The safety of synthetic zeolites used in detergents. Archives of toxicology, 83(1), (2009), pp.23-35. https://doi.org/10.1007/s00204-008-0327-5
[164] Z. Fakhravar, P. Ebrahimnejad, H. Daraee, and A. Akbarzadeh, Nanoliposomes: Synthesis methods and applications in cosmetics. Journal of Cosmetic and Laser Therapy, 18(3), (2016), pp.174-181. https://doi.org/10.3109/14764172.2015.1039040
[165] S. Tekmen, and S. Öksüz, Nanomaterials and Human Health. In Nanotoxicology and Nanoecotoxicology 1 (2021), (pp. 21-55). Springer, Cham. https://doi.org/10.1007/978-3-030-63241-0_2
[166] A. Gergely, and L. Coroyannakis, Nanotechnology in the EU cosmetics regulation. Household and Personal Care Today, 3, (2009), pp.28-30.
[167] C. Cardoza, V. Nagtode, A. Pratapa and S. N. Mali, Emerging applications of nanotechnology in cosmeceutical health science: Latest updates, Health Sciences Review 4(2022)100051 https://doi.org/10.1016/j.hsr.2022.100051