Green Chromatographic Purification of Pharmaceuticals


Green Chromatographic Purification of Pharmaceuticals

R.N. El-Shaheny, M.H. El-Maghrabey, M.I. Eid, N.M. El-Enany

Purification of active pharmaceutical ingredients is a crucial step in pharmaceutical manufacturing. The elimination of by-products, impurities, catalysts, coloring agents, and residual solvents is critical for the production of high-quality pharmaceutical products. This step is traditionally time-consuming, expensive, and consumes plentiful toxic organic solvents. With the global concern about green chemistry and sustainability, it becomes mandatory for the pharmaceutical industry to depend on greener purification techniques. This chapter highlights the green chromatographic techniques for purification of pharmaceuticals including counter-current chromatography, high-performance thin layer chromatography, gas chromatography, and supercritical fluid chromatography. As well, the most up-to-date applications of these green chromatographic purification techniques are included.

Supercritical Fluid Chromatography, Gas Chromatography, Countercurrent Chromatography, Thin Layer Chromatography, Green Purification, Pharmaceuticals

Published online 8/20/2019, 34 pages

Citation: R.N. El-Shaheny, M.H. El-Maghrabey, M.I. Eid, N.M. El-Enany, Green Chromatographic Purification of Pharmaceuticals, Materials Research Foundations, Vol. 54, pp 148-181, 2019


Part of the book on Industrial Applications of Green Solvents

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